Dear all,<div><br /></div><div>I am new user of cp2k and recently embarked on following the tutorial of QM/MM study of UREA Zwitterion in water(https://www.cp2k.org/exercises:2015_cecam_tutorial:urea). After perfoming that QM/MM tutorial, I am currently trying toadapt the related input file to compute the RESP of the urea molecule within an isolated water box. However, the RRSM is unexpectedly high, reaching 1.10320E+00. </div><div>I performed a separate DFT calculation of the urea molecule without water molecules, aiming to obtain the RESP. In this scenario, the RRSM values were significantly lower, measuring at 9.00126E-02 and 9.02948E-02 for periodic and non-periodic fitting, respectively.</div><div>I consulted the paper J. Phys. Chem., 97 , 10269-10280 (1993) and Phys. Chem. Chem. Phys., 17 , 14307-14316 (2015); the fitted potential is compared with the quantum mechanical (QM) potential. In these studys, only the urea molecule is treated at the QM level.<b> I am curious about substantial difference in RRSM values observed between the DFT calculations and the QM/MM simulation</b>. Would someone have idea about that?<br /><br />Best Regards,<br />Johnson</div><div><br /></div><div><br /></div>
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