Hi,<div><br /></div><div>I would like to calculate solvation free energy. I am familiar with free energy perturbation methods with force field based methods. I am not familiar with QM methods besides implicit solvation models. </div><div><br /></div><div>Are there QM methods using solvation boxes? Is this an application of metadynamics?</div><div><br /></div><div>Thanks,</div><div>Frank</div>
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