Hi...<div><br /></div><div>The problem here is not metadynamics, since less than 100 steps have been performed and metadynamics did not even start.</div><div>On the other hand the temperature is increasing to meaningless values, in particular the temperature of the QM subsystem.</div><div>Hence I would say that the problem is in the definition of the model. </div><div><br /></div><div>Regards</div><div>marcella<br /><br /></div><div class="gmail_quote"><div dir="auto" class="gmail_attr">On Saturday, April 1, 2023 at 6:47:14 AM UTC+2 Deeksha Vasudevan wrote:<br/></div><blockquote class="gmail_quote" style="margin: 0 0 0 0.8ex; border-left: 1px solid rgb(204, 204, 204); padding-left: 1ex;">I'm attaching the pdb file below. Kindly let me know what is the issue. Thanks.<br><br></blockquote></div>
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