<div><br></div>Hi<div><br></div><div>The QM box in your QMMM calculation is much larger. </div><div>A considerable amount of time is going into PW and FFT operations and calculation of QMMM forces</div><div><div> pw_transfer 1450 11.7 0.271 0.334 157.786 161.976</div><div> fft_wrap_pw1pw2 1282 12.8 0.028 0.036 155.109 159.276</div><div> fft_wrap_pw1pw2_150 822 14.0 17.073 19.058 151.008 154.414</div><div><div>qmmm_forces 4 3.8 0.001 0.003 117.781 117.782</div><div> qmmm_forces_with_gaussian 4 4.8 0.088 0.098 115.457 116.497</div><div> fft3d_ps 1282 14.8 63.372 66.540 107.554 110.807</div><div> pw_restrict_s3 12 5.8 31.639 32.981 101.177 102.309</div><div> qmmm_el_coupling 4 3.8 0.000 0.000 97.206 98.164</div><div> qmmm_elec_with_gaussian 4 4.8 0.062 0.104 97.185 98.142</div></div><div><br></div><div>Regards</div><div>Marcella</div><br></div><div class="gmail_quote"><div dir="auto" class="gmail_attr">On Wednesday, November 17, 2021 at 3:14:20 AM UTC+1 bnuyegu...@gmail.com wrote:<br/></div><blockquote class="gmail_quote" style="margin: 0 0 0 0.8ex; border-left: 1px solid rgb(204, 204, 204); padding-left: 1ex;">Dear all, <div><br></div><div> I have tested the molecular dynamics of the same molecule in the gas phase and in the QM/MM environment, and found that the SCF iteration of QM/MM is dozens of times slower than that of vacuum. Is this reasonable? As far as I know, the coupling between QM and MM should not affect the speed so much. </div><div><br></div><div>The input and output files for the tests are attached.</div><div><br></div><div><br><div><br></div><div><br></div></div></blockquote></div>
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