<div dir="ltr">Yes, but only in an ONIOMM like subtractive method. You wouldn't be able to electrostatically couple the two representations.<div><br></div><div><a href="https://www.cp2k.org/exercises:2015_cecam_tutorial:neb">https://www.cp2k.org/exercises:2015_cecam_tutorial:neb</a> might give you some ideas.<br><div><br></div><div>Matt<br><br>On Saturday, September 21, 2019 at 2:08:28 PM UTC+1, B Goldf wrote:<blockquote class="gmail_quote" style="margin: 0;margin-left: 0.8ex;border-left: 1px #ccc solid;padding-left: 1ex;">Dear Thomas<br>dear all,<p>is it possible to run<br>QM / "QM" <br>eg. DFT/SE like PBE / PM6  <br>via FORCE_MIXING<br>in cp2k,rather than QM/"MM"?</p><p>Best regards<br>Bernd</p><p></p></blockquote></div></div></div>